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AGN 195183

AGN 195183

  • CAT Number: I003352
  • CAS Number: 367273-07-2
  • Molecular Formula: C22H22ClF2NO4
  • Molecular Weight: 437.86
  • Purity: ≥95%
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AGN 195183 (Cat.No:I003352) (also known as Darapladib) is a potent inhibitor of Lp-PLA2, an enzyme involved in the formation of atherosclerotic plaques. It has been studied for its potential use in reducing cardiovascular risk in patients with coronary heart disease. AGN 195183 has shown promising results in clinical trials, but further research is needed.

Catalog Number I003352
CAS Number 367273-07-2
Molecular Formula

C22H22ClF2NO4

Purity 95%
Target RAR/RXR
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 3 nM (Kd); 200 nM (EC80, RAR Trans.)
IUPAC Name 4-[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]-2,6-difluorobenzoic acid
InChI InChI=1S/C22H22ClF2NO4/c1-21(2)5-6-22(3,4)16-12(21)9-11(18(27)17(16)23)19(28)26-10-7-13(24)15(20(29)30)14(25)8-10/h7-9,27H,5-6H2,1-4H3,(H,26,28)(H,29,30)
InChIKey PNAWUIKCVQSLFG-UHFFFAOYSA-N
SMILES CC1(CCC(C2=C1C=C(C(=C2Cl)O)C(=O)NC3=CC(=C(C(=C3)F)C(=O)O)F)(C)C)C
Reference

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<br>[1]. Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.
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