AGN 194310

• CAT Number: I002752
• CAS Number: 229961-45-9
• Molecular Formula: C28H24O2S
• Molecular Weight: 424.55
• Purity: ≥95%
• Synonyms: 4-((4-(4-ethylphenyl)-2,2-dimethyl-2H-thiochromen-6-yl)ethynyl)benzoic acid
• Target: RAR/RXR
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 3/2/5 nM (Kd for RARα/β/γ) [1][2]
• IUPAC Name: 4-[2-[4-(4-ethylphenyl)-2,2-dimethylthiochromen-6-yl]ethynyl]benzoic acid
• InChI: InChI=1S/C28H24O2S/c1-4-19-7-12-22(13-8-19)25-18-28(2,3)31-26-16-11-21(17-24(25)26)6-5-20-9-14-23(15-10-20)27(29)30/h7-18H,4H2,1-3H3,(H,29,30)
• InChIKey: LHUPKWKWYWOMSK-UHFFFAOYSA-N
• SMILES: O=C(O)C1=CC=C(C#CC2=CC(C(C3=CC=C(CC)C=C3)=CC(C)(C)S4)=C4C=C2)C=C1

AGN 194310 (Cat.No:I002752) is a selective antagonist of the dopamine D4 receptor that has been investigated as a potential treatment for schizophrenia and other psychiatric disorders. It has been shown to have high affinity for the D4 receptor and moderate to low affinity for other dopamine receptor subtypes.

Reference

[1]. Johnson AT, et al. Synthesis and biological activity of high-affinity retinoic acid receptor antagonists. Bioorg Med Chem. 1999 Jul;7(7):1321-38.

[2]. Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85(3):453-62.

[3]. Austenaa LM, et al. Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging. FASEB J. 2004 Aug;18(11):1255-7.

[4]. Walkley CR, et al. Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis. Leukemia. 2002 Sep;16(9):1763-72.