For research use only. Not for therapeutic Use.
AG-270（Cat No.:I044594）is a selective, orally bioavailable inhibitor of methionine adenosyltransferase 2A (MAT2A), an enzyme essential for S-adenosylmethionine (SAM) synthesis. It is designed to target tumors with methylthioadenosine phosphorylase (MTAP) deletion, a common genetic alteration in various cancers. By inhibiting MAT2A, AG-270 reduces SAM levels, disrupting methylation-dependent pathways crucial for cancer cell survival. This synthetic lethality approach selectively affects MTAP-deleted cells while sparing normal tissue. AG-270 has shown promising antitumor activity in preclinical models and is being explored as a precision oncology agent in early-phase clinical trials.
| CAS Number | 2201056-66-6 |
| Synonyms | 3-(cyclohexen-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-(pyridin-2-ylamino)-1H-pyrazolo[1,5-a]pyrimidin-7-one |
| Molecular Formula | C30H27N5O2 |
| Purity | ≥95% |
| IUPAC Name | 3-(cyclohexen-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-(pyridin-2-ylamino)-1H-pyrazolo[1,5-a]pyrimidin-7-one |
| InChI | InChI=1S/C30H27N5O2/c1-37-23-17-15-21(16-18-23)26-28(32-24-14-8-9-19-31-24)33-29-25(20-10-4-2-5-11-20)27(34-35(29)30(26)36)22-12-6-3-7-13-22/h3,6-10,12-19,34H,2,4-5,11H2,1H3,(H,31,32) |
| InChIKey | LSOYYWKBUKXUHQ-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C2=C(N=C3C(=C(NN3C2=O)C4=CC=CC=C4)C5=CCCCC5)NC6=CC=CC=N6 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
