For research use only. Not for therapeutic Use.
AFP464 (dihydrochloride)(CAT: I040212), also known as NSC710464 (dihydrochloride), is a hydrochloride salt form of AFP464, a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α) with an IC₅₀ of 0.25 μM. HIF-1α plays a central role in tumor adaptation to hypoxic conditions, making AFP464 a promising agent in cancer research. In addition to its HIF-1α inhibitory action, AFP464 functions as an activator of the aryl hydrocarbon receptor (AhR), contributing to its unique dual-mode mechanism. This compound is valuable for exploring hypoxia signaling, angiogenesis, and AhR-mediated transcriptional pathways in oncology and toxicology studies.
| Synonyms | (2S)-2,6-diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;dihydrochloride |
| Molecular Formula | C22H25Cl2F3N4O3 |
| Purity | ≥95% |
| IUPAC Name | (2S)-2,6-diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;dihydrochloride |
| InChI | InChI=1S/C22H23F3N4O3.2ClH/c1-10-18(24)20(28)17-15(30)9-16(32-21(17)19(10)25)11-5-6-14(12(23)8-11)29-22(31)13(27)4-2-3-7-26;;/h5-6,8-9,13H,2-4,7,26-28H2,1H3,(H,29,31);2*1H/t13-;;/m0../s1 |
| InChIKey | KWQPRUCXYQBCLR-GXKRWWSZSA-N |
| SMILES | CC1=C(C(=C2C(=O)C=C(OC2=C1F)C3=CC(=C(C=C3)NC(=O)C(CCCCN)N)F)N)F.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
