For research use only. Not for therapeutic Use.
ACT-678689 (CAT: I016439) is a potent tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM. TPH is the rate-limiting enzyme in serotonin biosynthesis and exists as two isoforms: TPH2, predominantly expressed in neuronal cells of the central nervous system (CNS), and TPH1, mainly localized in peripheral tissues such as enterochromaffin (EC) cells of the gut. By targeting TPH activity, ACT-678689 effectively modulates serotonin production, reducing peripheral 5-HT synthesis that contributes to circulating blood platelet storage, while offering potential utility in research focused on serotonergic regulation in neurological and peripheral disorders.
| CAS Number | 1783256-96-1 |
| Synonyms | N-[6-chloro-5-[2-[(12S)-12-(2-fluoro-4-methylphenyl)-4-methyl-5-thia-2,3,7,11-tetrazatricyclo[6.4.0.02,6]dodeca-1(8),3,6-trien-11-yl]-2-oxoethoxy]pyridin-2-yl]methanesulfonamide |
| Molecular Formula | C23H22ClFN6O4S2 |
| Purity | ≥95% |
| IUPAC Name | N-[6-chloro-5-[2-[(12S)-12-(2-fluoro-4-methylphenyl)-4-methyl-5-thia-2,3,7,11-tetrazatricyclo[6.4.0.02,6]dodeca-1(8),3,6-trien-11-yl]-2-oxoethoxy]pyridin-2-yl]methanesulfonamide |
| InChI | InChI=1S/C23H22ClFN6O4S2/c1-12-4-5-14(15(25)10-12)20-21-16(26-23-31(21)28-13(2)36-23)8-9-30(20)19(32)11-35-17-6-7-18(27-22(17)24)29-37(3,33)34/h4-7,10,20H,8-9,11H2,1-3H3,(H,27,29)/t20-/m0/s1 |
| InChIKey | XGWSHBGTWKYXMM-FQEVSTJZSA-N |
| SMILES | CC1=CC(=C(C=C1)C2C3=C(CCN2C(=O)COC4=C(N=C(C=C4)NS(=O)(=O)C)Cl)N=C5N3N=C(S5)C)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
