Acitretin

• CAT Number: A000540
• CAS Number: 55079-83-9
• Molecular Formula: C21H26O3
• Molecular Weight: 326.436
• Purity: ≥95%
• Target: RAR/RXR
• Solubility: >16.3mg/mL in DMSO
• Storage: -20°C
• IUPAC Name: (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
• InChI: InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
• InChIKey: IHUNBGSDBOWDMA-AQFIFDHZSA-N
• SMILES: CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC

Acitretin is an oral synthetic retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate (sc-205689). It has demonstrated an ability to suppress the development of chemically-induced epithelial tumors, as well as squamous cell carcinoma. Acitretin has potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis.

Reference

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