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ACHP Hydrochloride

ACHP Hydrochloride

  • CAT Number: I003482
  • CAS Number: 406209-26-5
  • Molecular Formula: C21H25ClN4O2
  • Molecular Weight: 400.9
  • Purity: ≥95%
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<p style=/line-height:25px/>ACHP Hydrochloride is a potent and selective IKK-2 inhibitor with IC50 of 8.5 nM.<br>IC50 value: 8.5 nM [1]<br>Target: IKK-2<br>ACHP Hydrochloride exhibited excellent in vitro profiles (IKK-beta IC(50)=8.5 nM, Cell IC(50)=60 nM) and a strong oral efficacy in in vivo anti-inflammatory assays (significant effects at 1mg/kg, po in arachidonic acid-induced ear edema model in mice).</p>

Catalog Number I003482
CAS Number 406209-26-5
Synonyms

(6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-4-yl-1H-pyridine-3-carbonitrile hydrochloride

Molecular Formula

C21H25ClN4O2

Purity 95%
Target IκB/IKK
Solubility 10 mM in DMSO
Storage Store at -20°C
IC50 8.5 nM [1]
Reference

<p style=/line-height:25px/>
<br>[1]. Murata T, et al. Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 3: Orally active anti-inflammatory agents. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4019-22.
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