Aceclofenac

• CAT Number: I005374
• CAS Number: 89796-99-6
• Molecular Formula: C16H13Cl2NO4
• Molecular Weight: 354.18
• Purity: ≥95%
• Target: COX
• Solubility: DMSO:≥20 mg/ml; methanol, and ethanol
• Storage: 2-8°C
• IUPAC Name: 2-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxyacetic acid
• InChI: InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
• InChIKey: MNIPYSSQXLZQLJ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)CC(=O)OCC(=O)O)NC2=C(C=CC=C2Cl)Cl

Aceclofenac（Cat No.:I005374） is a non-steroidal anti-inflammatory drug (NSAID) that acts as an analog of Diclofenac. It possesses anti-inflammatory, analgesic, and antipyretic properties. Aceclofenac inhibits the production of prostaglandins, which are responsible for mediating pain, inflammation, and fever. This medication is commonly prescribed for the treatment of various inflammatory conditions, including osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Aceclofenac provides relief from pain and inflammation, helping to improve joint mobility and overall quality of life for individuals suffering from these conditions.

Reference

1:Chitosan – Locust bean gum interpenetrating polymeric network nanocomposites for delivery of aceclofenac. Jana S, Sen KK.Int J Biol Macromol. 2017 Apr 26;102:878-884. doi: 10.1016/j.ijbiomac.2017.04.097. [Epub ahead of print] PMID: 28456644 2:Functionalized Lipid-Polymer Hybrid Nanoparticles Mediated Codelivery of Methotrexate and Aceclofenac: A Synergistic Effect in Breast Cancer with Improved Pharmacokinetics Attributes. Garg NK, Tyagi RK, Sharma G, Jain A, Singh B, Jain S, Katare OP.Mol Pharm. 2017 May 3. doi: 10.1021/acs.molpharmaceut.6b01148. [Epub ahead of print] PMID: 28402673 3:Efficacy and Safety of Different Aceclofenac Treatments for Chronic Lower Back Pain: Prospective, Randomized, Single Center, Open-Label Clinical Trials. Yang JH, Suk KS, Lee BH, Jung WC, Kang YM, Kim JH, Kim HS, Lee HM, Moon SH.Yonsei Med J. 2017 May;58(3):637-643. doi: 10.3349/ymj.2017.58.3.637. PMID: 28332372 Free PMC Article4:Efficacy and safety of aceclofenac in osteoarthritis: A meta-analysis of randomized controlled trials. Patel PB, Patel TK.Eur J Rheumatol. 2017 Mar;4(1):11-18. doi: 10.5152/eurjrheum.2017.160080. Epub 2017 Mar 1. PMID: 28293447 Free PMC Article5:Modulation of microenvironmental pH for dual release and reduced in vivo gastrointestinal bleeding of aceclofenac using hydroxypropyl methylcellulose-based bilayered matrix tablet. Kang WH, Nguyen HV, Park C, Choi YW, Lee BJ.Eur J Pharm Sci. 2017 May 1;102:85-93. doi: 10.1016/j.ejps.2017.02.039. Epub 2017 Mar 2. PMID: 28263912 6:Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study. Sharma G, Saini MK, Thakur K, Kapil N, Garg NK, Raza K, Goni VG, Pareek A, Katare OP.Nanomedicine (Lond). 2017 Mar;12(6):615-638. doi: 10.2217/nnm-2016-0405. Epub 2017 Feb 10. PMID: 28186461 7:An insight into the binding of aceclofenac with bovine serum albumin at physiological condition: a spectroscopic and computational approach. Dohare N, Khan AB, Maurya N, Thakur S, Athar F, Singh P, Patel R.J Biomol Struct Dyn. 2017 Jan 24:1-9. doi: 10.1080/07391102.2017.1278722. [Epub ahead of print] No abstract available. PMID: 28116972 8:Polymer based microspheres of aceclofenac as sustained release parenterals for prolonged anti-inflammatory effect. Kaur M, Sharma S, Sinha VR.Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:492-500. doi: 10.1016/j.msec.2016.11.092. Epub 2016 Nov 25. PMID: 28024613 9:Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity. Taşkıran M, Taşdemir A, Ayyıldız N.Brain Res Bull. 2017 Apr;130:42-46. doi: 10.1016/j.brainresbull.2016.12.010. Epub 2016 Dec 23. PMID: 28017780 10:Quality by Design (QbD)-enabled development of aceclofenac loaded-nano structured lipid carriers (NLCs): An improved dermatokinetic profile for inflammatory disorder(s). Garg NK, Sharma G, Singh B, Nirbhavane P, Tyagi RK, Shukla R, Katare OP.Int J Pharm. 2017 Jan 30;517(1-2):413-431. doi: 10.1016/j.ijpharm.2016.12.010. Epub 2016 Dec 9. PMID: 27956192