Acebilustat

• CAT Number: I005615
• CAS Number: 943764-99-6
• Molecular Formula: C29H27N3O4
• Molecular Weight: 481.54
• Purity: ≥95%
• Target: LTA4H
• Solubility: DMSO; Methanol: ≥ 32 mg/m
• Storage: Store at -20°C
• InChI: InChI=1S/C29H27N3O4/c33-29(34)23-5-1-20(2-6-23)16-31-18-25-15-24(31)19-32(25)17-21-3-9-26(10-4-21)36-27-11-7-22(8-12-27)28-30-13-14-35-28/h1-14,24-25H,15-19H2,(H,33,34)/t24-,25-/m0/s1
• InChIKey: GERJIEKMNDGSCS-DQEYMECFSA-N
• SMILES: O=C(O)C1=CC=C(CN2[C@](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[C@]3([H])C2)C=C1

Acebilustat is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory drug.
Acebilustat is an antiinflammatory drug in development for the treatment of CF and other diseases. It is a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils[2].

Reference

1:Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Elborn JS, Horsley A, MacGregor G, Bilton D, Grosswald R, Ahuja S, Springman EB.Clin Transl Sci. 2017 Jan;10(1):28-34. doi: 10.1111/cts.12428. Epub 2016 Nov 2. PMID: 27806191 2:Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Elborn JS, Bhatt L, Grosswald R, Ahuja S, Springman EB.Clin Transl Sci. 2017 Jan;10(1):20-27. doi: 10.1111/cts.12426. Epub 2016 Oct 28. PMID: 27792868