Acacetin

• CAT Number: I003689
• CAS Number: 480-44-4
• Molecular Formula: C16H12O5
• Molecular Weight: 284.26
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
• InChI: InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3
• InChIKey: DANYIYRPLHHOCZ-UHFFFAOYSA-N
• SMILES: OC1=CC(O)=C(C(C=C(C2=CC=C(OC)C=C2)O3)=O)C3=C1

Acacetin (Cat.No:I003689) is a flavonoid found in many plants, such as the Damiana plant. It has various biological activities, including anti-inflammatory, anti-cancer, and anti-viral properties. Acacetin can also act as an antioxidant, helping to protect cells from oxidative stress. It is used in traditional medicine to treat a range of ailments, including coughs, colds, and fever.

Reference

1:Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides. Jiang H, Yu J, Zheng H, Chen J, Wu J, Qi X, Wang Y, Wang X, Hu M, Zhu L, Liu Z.Pharm Res. 2017 Apr 18. doi: 10.1007/s11095-017-2157-8. [Epub ahead of print] PMID: 28421306 2:Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma. Zeng W, Zhang C, Cheng H, Wu YL, Liu J, Chen Z, Huang JG, Ericksen RE, Chen L, Zhang H, Wong AS, Zhang XK, Han W, Zeng JZ.Sci Rep. 2017 Mar 23;7(1):348. doi: 10.1038/s41598-017-00233-5. PMID: 28336971 Free PMC Article3:Analysis of tilianin and acacetin in Agastache rugosa by high-performance liquid chromatography with ionic liquids-ultrasound based extraction. Wei J, Cao P, Wang J, Kang W.Chem Cent J. 2016 Nov 29;10:76. eCollection 2016. PMID: 27994640 Free PMC Article4:Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury. Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR.Sci Rep. 2016 Nov 7;6:36435. doi: 10.1038/srep36435. PMID: 27819271 Free PMC Article5:Pharmacologic inhibition of autophagy sensitizes human acute leukemia Jurkat T cells to acacetin-induced apoptosis. Lee JY, Jun DY, Kim KY, Ha EJ, Woo MH, Ko JY, Yun YH, Oh IS, Kim YH.J Microbiol Biotechnol. 2016 Nov 4. doi: 10.4014/jmb.1610.10055. [Epub ahead of print] PMID: 27817185 Free Article6:Selective Anticancer Activity of Acacetin Against Chronic Lymphocytic Leukemia Using Both In Vivo and In Vitro Methods: Key Role of Oxidative Stress and Cancerous Mitochondria. Salimi A, Roudkenar MH, Sadeghi L, Mohseni A, Seydi E, Pirahmadi N, Pourahmad J.Nutr Cancer. 2016 Nov-Dec;68(8):1404-1416. Epub 2016 Oct 25. PMID: 27779444 7:Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B. Chaurasiya ND, Gogineni V, Elokely KM, León F, Núñez MJ, Klein ML, Walker LA, Cutler SJ, Tekwani BL.J Nat Prod. 2016 Oct 28;79(10):2538-2544. Epub 2016 Oct 18. PMID: 27754693 8:Acacetin Protects Mice from Staphylococcus aureus Bloodstream Infection by Inhibiting the Activity of Sortase A. Bi C, Dong X, Zhong X, Cai H, Wang D, Wang L.Molecules. 2016 Sep 26;21(10). pii: E1285. PMID: 27681715 Free Article9:Facile synthesis of acacetin and its derivatives. Zhao Y, Cai L, Sui Q, Lin F, Jiang W, Chen J, Lu W, Gao Q.Bioorg Med Chem Lett. 2016 Aug 1;26(15):3577-80. doi: 10.1016/j.bmcl.2016.06.018. Epub 2016 Jun 9. PMID: 27321812 10:Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs. Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR.Sci Rep. 2016 May 10;6:25743. doi: 10.1038/srep25743. PMID: 27160397 Free PMC Article