ABT-888

• CAT Number: I005439
• CAS Number: 912445-05-7
• Molecular Formula: C₁₃H₁₆N₄O.2HCl
• Molecular Weight: 317.21
• Purity: ≥95%
• Target: PARP
• Solubility: DMSO: ≥ 3.2 mg/mL
• Storage: Store at -20°C
• IC50: 5.2 nM(Ki for PARP1); 2.9 nM(Ki for PARP2)
• IUPAC Name: 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide;dihydrochloride
• InChI: InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1
• InChIKey: DSBSVDCHFMEYBX-FFXKMJQXSA-N
• SMILES: CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N.Cl.Cl

ABT-888 (Cat.No:I005439), also known as veliparib, is a small molecule inhibitor of poly (ADP-ribose) polymerase (PARP). It is used as a chemotherapy sensitizer and is being investigated for the treatment of cancer. It works by inhibiting the repair of damaged DNA in cancer cells, making them more susceptible to chemotherapy and radiation therapy. The compound has shown promising results in clinical trials for breast and ovarian cancer.

Reference

[1]. Donawho CK, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13(9):2728-37. 


[2]. Penning TD, et al. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem. 2009 Jan 22;52(2):514-23. 


[3]. Albert JM, et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res. 2007 May 15;13(10):3033-42.