ABT-724 trihydrochloride

• CAT Number: I010526
• CAS Number: 587870-77-7
• Molecular Formula: C17H22Cl3N5
• Molecular Weight: 402.75
• Purity: ≥95%
• Synonyms: 2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole;trihydrochloride
• InChI: InChI=1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H
• InChIKey: AZFUVPBLKQGSRI-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CC2=NC3=CC=CC=C3N2)C4=CC=CC=N4.Cl.Cl.Cl

ABT-724 trihydrochloride(CAT: I010526) is a potent and highly selective dopamine D₄ receptor agonist with an EC₅₀ of 12.4 nM for the human receptor. It functions as a partial agonist at rat (EC₅₀ = 14.3 nM) and ferret D₄ receptors (EC₅₀ = 23.2 nM), while showing negligible activity at D₁, D₂, D₃, and D₅ subtypes. ABT-724 displays exceptional selectivity, lacking affinity for over 70 neurotransmitter receptors, ion channels, and transporters at concentrations up to 10 μM, with only weak binding to 5-HT₁A receptors. In vivo, subcutaneous administration dose-dependently facilitates penile erection in conscious rats, supporting its potential in erectile dysfunction research.