Ablukast

• CAT Number: I021218
• CAS Number: 96566-25-5
• Molecular Formula: C28H34O8
• Molecular Weight: 498.56
• Purity: ≥95%
• Synonyms: 6-acetyl-7-[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentoxy]-3,4-dihydro-2H-chromene-2-carboxylic acid
• InChI: InChI=1S/C28H34O8/c1-4-8-21-23(12-10-20(17(2)29)27(21)31)34-13-6-5-7-14-35-26-16-25-19(15-22(26)18(3)30)9-11-24(36-25)28(32)33/h10,12,15-16,24,31H,4-9,11,13-14H2,1-3H3,(H,32,33)
• InChIKey: FGGYJWZYDAROFF-UHFFFAOYSA-N
• SMILES: CCCC1=C(C=CC(=C1O)C(=O)C)OCCCCCOC2=C(C=C3CCC(OC3=C2)C(=O)O)C(=O)C

Ablukast (Cat No.: I021218) is a potent leukotriene D4 (LTD4) receptor antagonist developed for the treatment of asthma and allergic disorders. By blocking LTD4 binding at cysteinyl leukotriene receptors (CysLT1), Ablukast inhibits bronchoconstriction, airway inflammation, and mucus secretion. Although not advanced to market, it has been widely employed in research as a selective CysLT1 antagonist and as an inhibitor of multidrug resistance protein 1 (MRP1)-mediated transport. Ablukast remains a valuable pharmacological tool in studying respiratory diseases, inflammation, and drug transport mechanisms.

Reference

[1]. M O’Donnell, et al. Pharmacological profile of Ro 23-3544, a new aerosol active leukotriene receptor antagonist. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:512-8.
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[2]. T Rosenbach, et al. Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis. Br J Dermatol. 1988 Jan;118(1):1-6.
[Content Brief]

[3]. Hans-Michael Eggenweiler, et al. Pyrrolopyrimidines as phosphodiesterase VII inhibitors. US7498334B2.