AA147

• CAT Number: I018131
• CAS Number: 393121-74-9
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.31
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
• InChI: InChI=1S/C16H17NO2/c1-12-7-9-15(18)14(11-12)17-16(19)10-8-13-5-3-2-4-6-13/h2-7,9,11,18H,8,10H2,1H3,(H,17,19)
• InChIKey: AWHLTHOHBAGPMY-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1)O)NC(=O)CCC2=CC=CC=C2

AA147（Cat No.:I018131） is a small molecule extracted from patent WO2017117430A1 that regulates endoplasmic reticulum (ER) proteostasis. It selectively activates the ATF6 arm of the unfolded protein response (UPR), which is responsible for cellular homeostasis. AA147 helps to restore ER function and reduce ER stress by modulating the protein folding pathway. AA147 has potential applications in the treatment of diseases associated with ER stress and proteostasis dysfunction, such as neurodegenerative diseases and cancer.

Reference

[1]. Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.