A939572

• CAT Number: I000191
• CAS Number: 1032229-33-6
• Molecular Formula: C20H22ClN3O3
• Molecular Weight: 387.9
• Purity: ≥95%
• Target: SCD
• Solubility: DMSO: ≥ 56 mg/mL
• Storage: Store at -20℃
• IC50: <4 nM (mSCD1); 37 nM (hSCD1) [1]
• IUPAC Name: 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
• InChI: InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)
• InChIKey: DPYTYQFYDLYWHZ-UHFFFAOYSA-N
• SMILES: ClC1=CC=CC=C1OC2CCN(C(NC3=CC(C(NC)=O)=CC=C3)=O)CC2

A939572 (Cat.No:I000191) is a selective, non-ATP competitive inhibitor of the cyclin-dependent kinase (CDK) 4/6. It is being studied for the treatment of various types of cancer, particularly those that involve the overexpression of cyclin D1. A939572 has shown potent anti-proliferative activity in preclinical studies and is currently undergoing clinical trials.

Reference

[1]. Xin Z, et al. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298-302.

[2]. von Roemeling CA, et al. Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res. 2013 May 1;19(9):2368-80.