A-770041

• CAT Number: I005231
• CAS Number: 869748-10-7
• Molecular Formula: C34H39N9O3
• Molecular Weight: 621.75
• Purity: ≥95%
• Target: Src
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 147 nM
• IUPAC Name: N-[4-[1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methylindole-2-carboxamide
• InChI: InChI=1S/C34H39N9O3/c1-21(44)41-14-16-42(17-15-41)24-9-11-25(12-10-24)43-33-30(32(35)36-20-37-33)31(39-43)23-8-13-26(29(19-23)46-3)38-34(45)28-18-22-6-4-5-7-27(22)40(28)2/h4-8,13,18-20,24-25H,9-12,14-17H2,1-3H3,(H,38,45)(H2,35,36,37)/t24-,25-
• InChIKey: ZMNWFTYYYCSSTF-SOAUALDESA-N
• SMILES: O/C(C(N1C)=CC2=C1C=CC=C2)=NC3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C(C)=O)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC

A-770041 (Cat.No:I005231) is a selective inhibitor of the receptor tyrosine kinase, c-Met, which is involved in cell growth, survival, and migration. It has been shown to inhibit c-Met activation and downstream signaling, leading to reduced tumor growth and metastasis in preclinical models. A-770041 may have potential as a therapeutic agent for various types of cancer.

Reference

1:A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. Duan Z, Zhang J, Ye S, Shen J, Choy E, Cote G, Harmon D, Mankin H, Hua Y, Zhang Y, Gray NS, Hornicek FJ.BMC Cancer. 2014 Sep 19;14:681. doi: 10.1186/1471-2407-14-681. PMID: 25236161 Free PMC Article2:Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF.Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID: 16216497 3:A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection. Stachlewitz RF, Hart MA, Bettencourt B, Kebede T, Schwartz A, Ratnofsky SE, Calderwood DJ, Waegell WO, Hirst GC.J Pharmacol Exp Ther. 2005 Oct;315(1):36-41. Epub 2005 Jul 12. PMID: 16014572 Free Article