A 77-01

• CAT Number: I004289
• CAS Number: 607737-87-1
• Molecular Formula: C18H14N4
• Molecular Weight: 286.3
• Purity: ≥95%
• Target: TGF-βR1(ALK5)
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 25 nM [1]
• InChI: InChI=1S/C18H14N4/c1-12-5-4-8-17(21-12)18-15(11-20-22-18)13-9-10-19-16-7-3-2-6-14(13)16/h2-11H,1H3,(H,20,22)
• InChIKey: KJTYZDORHCDZPS-UHFFFAOYSA-N
• SMILES: CC1=NC(C2=NNC=C2C3=CC=NC4=C3C=CC=C4)=CC=C1

A 77-01(CAT: I004289) is a potent inhibitor targeting the TGF-β type I receptor superfamily activin-like kinase ALK5, displaying an impressive IC50 value of 25 nM. This compound’s ability to selectively block ALK5 activity holds the potential for modulating TGF-β signaling pathways, making it a valuable tool for studying the complex roles of TGF-β in various biological processes and diseases. A 77-01’s specific mechanism of action on ALK5 inhibition may contribute to advancing our understanding of TGF-β-related pathways and potentially offering new avenues for therapeutic interventions.

Reference

1:Klin Padiatr. 1981 May;193(3):137-44. [All 77-01 therapy study for treatment of acute lymphocytic leukemia in childhood (author/’s transl)].Haas RJ,Janka G,Netzel B,Helmig M, PMID: 6943386 DOI: 10.1055/s-2008-1034449