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A-485

A-485

  • CAT Number: I013011
  • CAS Number: 1889279-16-6
  • Molecular Formula: C₂₅H₂₄F₄N₄O₅
  • Molecular Weight: 536.48
  • Purity: ≥95%
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A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively.

Catalog Number I013011
CAS Number 1889279-16-6
Molecular Formula

C₂₅H₂₄F₄N₄O₅

Purity 95%
Target Epigenetic Reader Domain Histone Acetyltransferase
Solubility DMSO: ≥ 250 mg/mL
IUPAC Name N-[(4-fluorophenyl)methyl]-2-[(3R)-6-(methylcarbamoylamino)-2//',4//'-dioxospiro[1,2-dihydroindene-3,5//'-1,3-oxazolidine]-3//'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide
InChI InChI=1S/C25H24F4N4O5/c1-14(25(27,28)29)32(12-15-3-5-17(26)6-4-15)20(34)13-33-21(35)24(38-23(33)37)10-9-16-11-18(7-8-19(16)24)31-22(36)30-2/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,30,31,36)/t14-,24+/m0/s1
InChIKey VRVJKILQRBSEAG-LFPIHBKWSA-N
SMILES CC(C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)C3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O
Reference

[1]. Lasko LM, et al. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2017 Oct 5;550(7674):128-132.

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