PROPYBICYPHAT


CAS No. : 51486-74-9

PROPYBICYPHAT,51486-74-9
Product Details
Cat No:T000139
Molecular Formula:C7H13O4P
Molecular Weight:192.151
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Melting Point:234-236 °C.
Purity:95 % (NMR).
Cat No:T000139
Cas No:51486-74-9
Product-Name:PROPYBICYPHAT
IUPAC Name:4-propyl-2,6,7-trioxa-1$l^{5}
InChI:InChI=1S/C7H13O4P/c1-2-3-7-4-9-12(8,10-5-7)11-6-7/h2-6H2,1H3
InChIKey:UQIFWHFHQUNJBT-UHFFFAOYSA-N
SMILES:CCCC12COP(=O)(OC1)OC2

a GABA-gated chloride channel blocker, non-competitive GABA antagonist in mammals.


Organophosphorous compound,, synthetic.

(IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 0.5 nM;
inhibition of the GABA-dependent Cl- current at 1.09 nM;
(IC50) for [3H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 �M (Ticku M.);
(IC50) for [35S]-tert.butyl-thionebicyclophosphate binding with the human brain membranes: 1.1 �M (Casida J.);
experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Flunitrazepam) showed no influence of Propybicyphat up to 10 �M.


- Bellet et al., Science.(1973) 182:1135-1136

- Squires et al., Mol. Pharmacol.(1983) 23:326-336

- Fetisov et al., Biol. Membr. (1986) (Russian). 3(5):968-970

- Cooper et al., Mol. Pharmacol. (1983). 23:207-212



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