(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Methyl Ester


CAS No. : 65919-53-1

(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Methyl Ester,65919-53-1
Product Details
Cat No:R062977
Synonyms:(6Z,9Z,12Z,15Z,18Z)-6,9,12,15,18-Heneicosapentaenoic Acid Methyl Ester
Molecular Formula:C22H34O2
Molecular Weight:330.512
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Assay:≥98%
Appearance:A solution in ethanol
Cat No:R062977
Cas No:65919-53-1
Product-Name:(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid Methyl Ester
IUPAC Name:methyl (6Z,9Z,12Z,15Z,18Z)-henicosa-6,9,12,15,18-pentaenoate
InChI:InChI=1S/C22H34O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-2/h4-5,7-8,10-11,13-14,16-17H,3,6,9,12,15,18-21H2,1-2H3/b5-4-,8-7-,11-10-,14-13-,17-16-
InChIKey:VWHAHPVYEMPWTO-JEBPEJKESA-N
SMILES:CCC=CCC=CCC=CCC=CCC=CCCCCC(=O)OC
Heneicosapentaenoic Acid (HPA) is a fatty acid present in trace amounts in the green algae Bryopsis pennata Lamouroux and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the Δ HPA can be used to study the significance of the position of the double bonds in n-3 fatty acids. It incorporates into phospholipids and into triacylglycerol in vivo with the same efficiency as EPA and docosahexaenoic acid (DHA) and exhibits strong inhibition of arachidonic acid synthesis from linoleic acid. HPA is a poor substrate for prostaglandin H (PGH) synthase and for 5-lipoxygenase but retains the ability to rapidly inactivate PGH synthase. In certain formulations, HPA methyl ester may serve as a prodrug, which should facilitate uptake of HPA and then be hydrolyzed by esterases to generate the free acid once incorporated into cells. It may also be useful as a reference standard in analytical work.
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