(+)-D-threo-PDMP (hydrochloride)

CAS No. : 139889-62-6

(+)-D-threo-PDMP (hydrochloride),139889-62-6
Product Details
Cat No:R043772
Synonyms:N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride
Molecular Formula:C23H38N2O3 • HCl
Molecular Weight:427.0
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Cat No:R043772
Cas No:139889-62-6
Product-Name:(+)-D-threo-PDMP (hydrochloride)
(+)-D-threo-PDMP is a glucosylceramide (GlyCer) synthetase inhibitor with an IC50 value of 5 µM in vitro. The (+)-D-threo (1R,2R) isomer is the active inhibitory component of the racemic DL-threo-PDMP (Item No. 10005276). In vitro, (+)-D-threo-PDMP inhibits the synthesis of GlyCer and lactosylceramide in B16 melanoma cells and inhibits cell binding to laminin and collagen with IC50 values of 10-25 µM.
1.Vunnam, R.R., and Radin, N.S. Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain. Chemistry and Physics of Lipids 26, 265-278 (1980).
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