PF-543 HCl

CAS No. : 1706522-79-3 (HCl)

PF-543 HCl,1706522-79-3 (HCl)
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:R018798
Synonyms:PF-543 HCl;(R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol hydrochoride
Molecular Formula:C27H32ClNO4S
Molecular Weight:502.066
Target:SK-1 inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:R018798
Cas No:1706522-79-3 (HCl)
Product-Name:PF-543 HCl
PF-543 is a novel selective SK-1 inhibitor which inhibited SK-1 activity in a competitive manner with sphingosine. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. PF-543 was effective as a potent inhibitor of S1P formation in whole blood, indicating that the SphK1 isoform of sphingosine kinase is the major source of S1P in human blood. PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling.

1: Lynch KR. Building a better sphingosine kinase-1 inhibitor. Biochem J. 2012 May 15;444(1):e1-2. doi: 10.1042/BJ20120567. PubMed PMID: 22533672.
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