MT7 – Muscarinic Toxin 7


CAS No. :

MT7 – Muscarinic Toxin 7,
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:P000404
Molecular Formula:C322H484N90O98S9
Molecular Weight:7472.53 Da
Target:Blocker of M1-subtype of muscarinic receptor
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Appearance: White lyophilized solid
Purity rate: > 98%
AA sequence: LTC3VKSNSIWFPTSEDC17PDGQNLC24FKRWQYISPRMYDFTRGC42AATC46PKAEYRDVINC57C58GTDKC63NK
Disulfide bonds: Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, Cys58-Cys63
Length (aa): 65
Cat No:P000404
Product-Name:MT7 – Muscarinic Toxin 7
Muscarinic toxin 7 (MT7 – m1-toxin 1) has been isolated from the venom of the green mamba (Dendroaspis Angusticeps). MT7 potently blocks M1-subtype of muscarinic acetylcholine receptors at a subnanomolar affintiy. Muscarinic acetylcholine receptors are G-protein coupled receptors that mediate the metabotropic effects of acetylcholine. M1-type muscarinic acetylcholine receptors are well known therapeutic targets to improve cognitive functions in patients with Alzheimer disease. Contrary to many ligands that target mAChRs (pirenzepine, carbamoylcholine chloride, 4-DAMP or atropine), MT7 is the most selective M1-subtype antagonist as it is about 10,000 times more selective for M1-subtype than other subtypes. MT7 toxin is an ideal tool to identify the muscarinic receptor subtype expression in tissues for example. MT7 toxin belongs to the three finger toxin family such as rho-Da1a.

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