| Appearance: | Solid powder |
| Purity: | 98% |
| Cat No: | M131816 |
| Cas No: | 160498-02-2 |
| Product-Name: | Bisandrographolide C |
| IUPAC Name: | 4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2-[2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]-1-(5-oxo-2H-furan-4-yl)ethyl]-2H-furan-5-one |
| InChI: | InChI=1S/C40H56O8/c1-23-7-11-31-37(3,16-13-33(43)39(31,5)21-41)28(23)10-9-25-19-30(48-35(25)45)27(26-15-18-47-36(26)46)20-29-24(2)8-12-32-38(29,4)17-14-34(44)40(32,6)22-42/h9-10,15,19,27-34,41-44H,1-2,7-8,11-14,16-18,20-22H2,3-6H3/b10-9+/t27?,28-,29-,30?,31+,32+,33-,34-,37+,38+,39+,40+/m1/s1 |
| InChIKey: | WQHWOZANSOUSAY-LZBAHHAZSA-N |
| SMILES: | CC12CCC(C(C1CCC(=C)C2CC(C3C=C(C(=O)O3)C=CC4C(=C)CCC5C4(CCC(C5(C)CO)O)C)C6=CCOC6=O)(C)CO)O |
Bisandrographolide C (CAS 160498-02-2) is a natural diterpenoid found in the herbs of Andrographis paniculata (Burm. f.) Nees. Andrographolide, a diterpenoid lactone, is one of the potent bioactive compounds isolated from Andrographis paniculata, shows bioactivities such as cytotoxicity, immunomodulation, hepatoprotectivity, apoptosis induction, and activates calcium‑permeable protein channel called transient receptor potential channels (TRPV4).
1.Niranjan Reddy, V. L., et al. "A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity." Natural Product Research 19.3 (2005): 223-230.
2.Raghavan, Rahul, Sanith Cheriyamundath, and Joseph Madassery. "Exploring the mechanisms of cytotoxic and anti-inflammatory property of andrographolide and its derivatives." Pharmacognosy Reviews 12.23 (2018).
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