((addition))-DHMEQ


CAS No. : 287194-41-6

((addition))-DHMEQ,287194-41-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I013760
Molecular Formula:C₁₃H₁₁NO₅
Molecular Weight:261.23
Target: NF-κB
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

refresh
Cat No:I013760
Cas No:287194-41-6
Product-Name:((addition))-DHMEQ
IUPAC Name:2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide
InChI:InChI=1S/C13H11NO5/c15-8-4-2-1-3-6(8)13(18)14-7-5-9(16)11-12(19-11)10(7)17/h1-5,10-12,15,17H,(H,14,18)/t10-,11+,12-/m1/s1
InChIKey:IUOMATKBBPCLFR-GRYCIOLGSA-N
SMILES:C1=CC=C(C(=C1)C(=O)NC2=CC(=O)C3C(C2O)O3)O
The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-κB. In vitro: (+)-DHMEQ down-regulat the NF-κB target genes IRF4 and CD40, the secretion of IL-6, CCL5, CCL17 and generated ROS. Cytotoxicity, CD30 down-modulation and CD30 shedding by (+)-DHMEQ are prevented by ROS scavenger NAC. [1] (+)-DHMEQ is a novel NF-κB inhibitor that induces apoptosis and cell-cycle arrest in several cancer cell types and promotes ROS generation, which causes genotoxic DNA damage in human liver cells. [2]
[1]. Celegato M et al. The NF-κB inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironmentand synergizes with chemotherapy agents in classical Hodgkin lymphoma. Cancer Lett. 2014 Jul 10;349(1):26-34.
[2]. Lampiasi N et al. Poly (ADP-ribose) polymerase inhibition synergizes with the NF-κB inhibitor DHMEQ to kill hepatocellular carcinoma cells. Biochim Biophys Acta. 2014 Nov;1843(11):2662-73.
[3]. Matsumoto N et al. Synthesis of NF-kappaB activation inhibitors derived from epoxyquinomicin C. Bioorg Med Chem Lett. 2000 May 1;10(9):865-9.
[4]. Yoshikazu Suzuki et al. Preparation and biological activities of optically active dehydroxymethylepoxyquinomicin, a novel NF-κB inhibitor. Tetrahedron. Tetrahedron 60 (2004) 7061-7066
Related Products
  • CAS No. :471-87-4
    Product Name:

    Stachydrine

    Cat No: I013688 View details
  • CAS No. :796854-35-8
    Product Name:

    WAY-204688

    Cat No: I013513 View details
  • CAS No. :213546-53-3
    Product Name:

    SN50

    Cat No: I013644 View details