((addition))-SJ733


CAS No. : 1424799-20-1

((addition))-SJ733,1424799-20-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I013048
Molecular Formula:C₂₄H₁₆F₄N₄O₂
Molecular Weight:468.4
Target: Na+/K+ ATPase Parasite
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Cat No:I013048
Cas No:1424799-20-1
Product-Name:((addition))-SJ733
IUPAC Name:(3S,4S)-N-(3-cyano-4-fluorophenyl)-1-oxo-3-pyridin-3-yl-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinoline-4-carboxamide
InChI:InChI=1S/C24H16F4N4O2/c25-19-8-7-16(10-15(19)11-29)31-22(33)20-17-5-1-2-6-18(17)23(34)32(13-24(26,27)28)21(20)14-4-3-9-30-12-14/h1-10,12,20-21H,13H2,(H,31,33)/t20-,21+/m0/s1
InChIKey:VKCPFWKTFZAOTO-LEWJYISDSA-N
SMILES:C1=CC=C2C(=C1)C(C(N(C2=O)CC(F)(F)F)C3=CN=CC=C3)C(=O)NC4=CC(=C(C=C4)F)C#N
(+)-SJ733 is a clinical candidate for malaria which can also inhibit Na+-ATPase PfATP4.
[1]. Jiménez-Díaz MB, et al. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62.
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