MK 386


CAS No. : 158493-17-5

MK 386,158493-17-5
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I011318
Synonyms:(4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one
Molecular Formula:C28H49NO
Molecular Weight:415.706
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Cat No:I011318
Cas No:158493-17-5
Product-Name:MK 386
IUPAC Name:(1R,3aS,3bS,4S,5aR,9aR,9bS,11aR)-4,6,9a,11a-tetramethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1H-indeno[5,4-f]quinolin-7-one
InChI:InChI=1S/C28H49NO/c1-18(2)9-8-10-19(3)21-11-12-22-26-20(4)17-24-28(6,16-14-25(30)29(24)7)23(26)13-15-27(21,22)5/h18-24,26H,8-17H2,1-7H3/t19-,20+,21-,22+,23+,24-,26+,27-,28-/m1/s1
InChIKey:XUTZDXHKQDPUMA-MVJJLJOTSA-N
SMILES:CC1CC2C(CCC(=O)N2C)(C3C1C4CCC(C4(CC3)C)C(C)CCCC(C)C)C
Potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50 = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50 = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.
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