MK 386

CAS No. : 158493-17-5

MK 386,158493-17-5
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I011318
Molecular Formula:C28H49NO
Molecular Weight:415.706
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Cat No:I011318
Cas No:158493-17-5
Product-Name:MK 386
IUPAC Name:(1R,3aS,3bS,4S,5aR,9aR,9bS,11aR)-4,6,9a,11a-tetramethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1H-indeno[5,4-f]quinolin-7-one
Potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50 = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50 = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.
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