GSK-626616


CAS No. : 1025821-33-3

GSK-626616,1025821-33-3
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I007119
Synonyms:GSK-626616; GSK 626616; GSK626616.;(5Z)-2-(2,6-Dichloroanilino)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolone
Molecular Formula:C18H10Cl2N4OS
Molecular Weight:401.265
Target:YAK3/DYRK3 kinase inhibitor
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Inventory Status:In stock!
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Appearance:Solid powder
Purity: > 98%
Cat No:I007119
Cas No:1025821-33-3
Product-Name:GSK-626616
IUPAC Name:(5Z)-2-(2,6-dichloroanilino)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazol-4-one
InChI:InChI=1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9-
InChIKey:RJPNRXFBYZVRIB-DHDCSXOGSA-N
SMILES:C1=CC(=C(C(=C1)Cl)NC2=NC(=O)C(=CC3=CC4=NC=CN=C4C=C3)S2)Cl
GSK 626616 is a YAK3/DYRK3 kinase inhibitor. It is a chemoprotective agent for the potential treatment of chemotherapy-induced anaemia.

1: Wippich F, Bodenmiller B, Trajkovska MG, Wanka S, Aebersold R, Pelkmans L. Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell. 2013 Feb 14;152(4):791-805. doi: 10.1016/j.cell.2013.01.033. PubMe
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