(-)-Epigallocatechin


CAS No. : 970-74-1

(-)-Epigallocatechin,970-74-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I005708
Synonyms:(2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol
Molecular Formula:C15H14O7
Molecular Weight:306.3
Target:PKC
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Appearance:Solid powder
Purity: > 98%
Cat No:I005708
Cas No:970-74-1
Product-Name:(-)-Epigallocatechin
InChIKey:XMOCLSLCDHWDHP-IUODEOHRSA-N

(-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils. 

in vitro: EGCG is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that EGCG prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and EGCG specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. EGCG exhibited a MIC and MBC of 5μg/mL and 20μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, EGCG induced significant down-regulation of E. faecalis virulence genes [3].


1:Morphometric abnormalities in the spleen of the progeny of mice fed epigallocatechin during gestation and nursing. Bałan BJ, Skopińska-Różewska E, Skopiński P, Zdanowski R, Leśniak M, Kiepura A, Lewicki S.Pol J Vet Sci. 2017 Mar 28;20(1):5-12. doi: 10.1515/pjvs-2017-0001. PMID: 28525335
2:(-)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer/'s disease. Guo Y, Zhao Y, Nan Y, Wang X, Chen Y, Wang S.Neuroreport. 2017 May 17. doi: 10.1097/WNR.0000000000000803. [Epub ahead of print] PMID: 28520620
3:Bioinformatics Analysis on Molecular Mechanism of Green tea Compound Epigallocatechin-3-Gallate Against Ovarian Cancer. Xinqiang S, Mu Z, Lei C, Mun LY.Clin Transl Sci. 2017 May 15. doi: 10.1111/cts.12470. [Epub ahead of print] PMID: 28504421
4:Comparison of the impact of epigallocatechin gallate and ellagic acid in an experimental cataract model induced by sodium selenite. Ergen I, Turgut B, Ilhan N.Int J Ophthalmol. 2017 Apr 18;10(4):499-506. doi: 10.18240/ijo.2017.04.01. eCollection 2017. PMID: 28503419 Free PMC Article
5:Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains. Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg MH, Kim C.J Biol Chem. 2017 May 9. pii: jbc.C117.787309. doi: 10.1074/jbc.C117.787309. [Epub ahead of print] PMID: 28487468 Free Article
6:Effect of epigallocatechin-3-gallate on the increase in type II collagen accumulation in cartilage-like MSC sheets. Sato K, Mera H, Wakitani S, Takagi M.Biosci Biotechnol Biochem. 2017 Jun;81(6):1241-1245. doi: 10.1080/09168451.2017.1282809. Epub 2017 Feb 28. PMID: 28485205
7:Epigallocatechin gallate inhibits the growth of salivary adenoid cystic carcinoma cells via the EGFR/Erk signal transduction pathway and the mitochondria apoptosis pathway. Weng LX, Wang GH, Yao H, Yu MF, Lin J.Neoplasma. 2017 May 9;64. doi: 10.4149/neo_2017_410. [Epub ahead of print] PMID: 28485162
8:Epigallocatechin-3-gallate counters cisplatin toxicity of rat testes. Fouad AA, Qutub HO, Fouad AEA, Audeh AM, Al-Melhim WN.Pharm Biol. 2017 Dec;55(1):1710-1714. doi: 10.1080/13880209.2017.1322618. PMID: 28478745
9:Epigallocatechin-3-gallate ameliorates hypoxia-induced pulmonary vascular remodeling by promoting mitofusin-2-mediated mitochondrial fusion. Zhu TT, Zhang WF, Luo P, He F, Ge XY, Zhang Z, Hu CP.Eur J Pharmacol. 2017 May 3. pii: S0014-2999(17)30306-0. doi: 10.1016/j.ejphar.2017.05.003. [Epub ahead of print] PMID: 28478070
10:Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes. Stringer M, Abeysekera I, Thomas J, LaCombe J, Stancombe K, Stewart RJ, Dria KJ, Wallace JM, Goodlett CR, Roper RJ.Physiol Behav. 2017 May 3;177:230-241. doi: 10.1016/j.physbeh.2017.05.003. [Epub ahead of print] PMID: 28478033
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