LY 3000328


CAS No. : 1373215-15-6

LY 3000328,1373215-15-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I001435
Synonyms:[(3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl] N-methylcarbamate;LY 3000328;LY3000328;Z-FL-COCHO
Molecular Formula:C25H29FN4O5
Molecular Weight:484.52
Target:Cathepsin
Price:Get quote
Inventory Status:In stock!
We would like to match the lowest price on market if possible.

Your information is safe with us.

refresh
Appearance:Solid powder
Purity: > 98%
Cat No:I001435
Cas No:1373215-15-6
Product-Name:LY 3000328
IUPAC Name:[(3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl] N-methylcarbamate
InChI:InChI=1S/C25H29FN4O5/c1-27-25(32)35-22-15-34-21-7-6-18(29-8-10-30(11-9-29)19-13-33-14-19)12-20(21)23(22)28-24(31)16-2-4-17(26)5-3-16/h2-7,12,19,22-23H,8-11,13-15H2,1H3,(H,27,32)(H,28,31)/t22-,23-/m0/s1
InChIKey:NDEBZCZEAVMSQF-GOTSBHOMSA-N
SMILES:CNC(=O)OC1COC2=C(C1NC(=O)C3=CC=C(C=C3)F)C=C(C=C2)N4CCN(CC4)C5COC5

LY 3000328(cas 1373215-15-6) is a novel Cathepsin S inhibitor. LY 3000328 is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases.


[1]. Lee-Dutra A, Wiener DK, Sun S. Cathepsin S inhibitors: 2004-2010. Expert Opin Ther Pat. 2011 Mar;21(3):311-37. doi: 10.1517/13543776.2011.553800.
[2]. J. M. Wiener, John; Sun, et al. Recent Advances in the Design of Cathepsin S Inhibitors. Current Topics in Medicinal Chemistry, 2010, 10, (7): 717-732(16).
[3]. Link JO, Zipfel S. Advances in cathepsin S inhibitor design. Curr Opin Drug Discov Devel. 2006 Jul;9(4):471-82.

Related Products
  • CAS No. :429676-93-7
    Product Name:

    Cathepsin G Inhibitor

    Cat No: R060915 View details
  • CAS No. :225120-65-0
    Product Name:

    Cathepsin Inhibitor 1

    Cat No: I010449 View details
  • CAS No. :88191-84-8
    Product Name:

    MDL 28170

    Cat No: R016189 View details
  • CAS No. :294623-49-7
    Product Name:

    L006235

    Cat No: I007546 View details