LY 3000328

CAS No. : 1373215-15-6

LY 3000328,1373215-15-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I001435
Synonyms:[(3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl] N-methylcarbamate;LY 3000328;LY3000328;Z-FL-COCHO
Molecular Formula:C25H29FN4O5
Molecular Weight:484.52
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Inventory Status:In stock!
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Appearance:Solid powder
Purity: > 98%
Cat No:I001435
Cas No:1373215-15-6
Product-Name:LY 3000328
IUPAC Name:[(3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl] N-methylcarbamate

LY 3000328(cas 1373215-15-6) is a novel Cathepsin S inhibitor. LY 3000328 is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases.

[1]. Lee-Dutra A, Wiener DK, Sun S. Cathepsin S inhibitors: 2004-2010. Expert Opin Ther Pat. 2011 Mar;21(3):311-37. doi: 10.1517/13543776.2011.553800.
[2]. J. M. Wiener, John; Sun, et al. Recent Advances in the Design of Cathepsin S Inhibitors. Current Topics in Medicinal Chemistry, 2010, 10, (7): 717-732(16).
[3]. Link JO, Zipfel S. Advances in cathepsin S inhibitor design. Curr Opin Drug Discov Devel. 2006 Jul;9(4):471-82.

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