AEG40826


CAS No. : 1107664-44-7

AEG40826,1107664-44-7
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000416
Synonyms:HGS1029; HGS-1029; HGS 1029; AEG40826; AEG-40826; AEG 40826; AEG408262 HCl.;NONE
Molecular Formula:C8H11ClFNO2S
Target:IAP Inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:I000416
Cas No:1107664-44-7
Product-Name:AEG40826
AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. IAPs are overexpressed by many cancer cell types, suppressing apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their BIR (baculoviral lAP repeat) domains.

 
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