CAS No. : 30827-99-7 (HCl)

AEBSF HCl,30827-99-7 (HCl)
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000372
Synonyms:AEBSF hydrochloride; AEBSF HCl.;4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride
Molecular Formula:C8H11ClFNO2S
Molecular Weight:239.689
Target:serine protease inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:I000372
Cas No:30827-99-7 (HCl)
Product-Name:AEBSF HCl
IUPAC Name:4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
MDL No:MFCD00132962
AEBSF is a specific irreversible serine protease inhibitor. AEBSF inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Both AEBSF and PMSF are sulfonyl fluorides and are sulfonylating agents. Sulfonyl fluorides act by reacting with the hydroxy group of the active site serine residue to form a sulfonyl enzyme derivative. This derivative may be stable for long periods of time except at high pH.

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2: Saw S, Arora N. PI3K and ERK1/2 kinase inhibition potentiate protease inhibitor to attenuate allergen induced Th2 immune response in mouse. Eur J Pharmacol. 2016 Apr 5;776:176-84. doi: 10.1016/j.ejphar.2016.02.050. Epub 2016 Feb 18. PubMed PMID: 26905476.
3: Chai HJ, Kiew LV, Chin Y, Norazit A, Mohd Noor S, Lo YL, Looi CY, Lau YS, Lim TM, Wong WF, Abdullah NA, Abdul Sattar MZ, Johns EJ, Chik Z, Chung LY. Renal targeting potential of a polymeric drug carrier, poly-l-glutamic acid, in normal and diabetic rats. Int J Nanomedicine. 2017 Jan 13;12:577-591. doi: 10.2147/IJN.S111284. eCollection 2017. PubMed PMID: 28144140; PubMed Central PMCID: PMC5245978.
4: Saw S, Kale SL, Arora N. Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. PLoS One. 2012;7(7):e41107. doi: 10.1371/journal.pone.0041107. Epub 2012 Jul 19. PubMed PMID: 22829914; PubMed Central PMCID: PMC3400607.
5: Huffman NT, Keightley JA, Chaoying C, Midura RJ, Lovitch D, Veno PA, Dallas SL, Gorski JP. Association of specific proteolytic processing of bone sialoprotein and bone acidic glycoprotein-75 with mineralization within biomineralization foci. J Biol Chem. 2007 Sep 7;282(36):26002-13. Epub 2007 Jul 5. PubMed PMID: 17613519; PubMed Central PMCID: PMC2805412.
6: Buitrago-Rey R, Olarte J, Gomez-Marin JE. Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis. J Antimicrob Chemother. 2002 May;49(5):871-4. PubMed PMID: 12003987.
7: Sun ZG, Shi HJ, Gu Z, Wang J, Shen QX. A single intrauterine injection of the serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride reversibly inhibits embryo implantation in mice. Contraception. 2007 Sep;76(3):250-5. Epub 2007 Jul 5. PubMed PMID: 17707725.
8: Gorski JP, Huffman NT, Chittur S, Midura RJ, Black C, Oxford J, Seidah NG. Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. J Biol Chem. 2011 Jan 21;286(3):1836-49. doi: 10.1074/jbc.M110.151647. Epub 2010 Nov 12. PubMed PMID: 21075843; PubMed Central PMCID: PMC3023479.
9: Blatnik M, Soderstrom CI. A practical guide for the stabilization of acylghrelin in human blood collections. Clin Endocrinol (Oxf). 2011 Mar;74(3):325-31. doi: 10.1111/j.1365-2265.2010.03916.x. PubMed PMID: 21050250.
10: Yokoe M, Sano M, Shibata H, Shibata D, Takayama-Watanabe E, Inaba K, Watanabe A. Sperm proteases that may be involved in the initiation of sperm motility in the newt, Cynops pyrrhogaster. Int J Mol Sci. 2014 Aug 28;15(9):15210-24. doi: 10.3390/ijms150915210. PubMed PMID: 25170808; PubMed Central PMCID: PMC4200841.
11: Park IC, Park MJ, Choe TB, Jang JJ, Hong SI, Lee SH. TNF-alpha induces apoptosis mediated by AEBSF-sensitive serine protease(s) that may involve upstream caspase-3/CPP32 protease activation in a human gastric cancer cell line. Int J Oncol. 2000 Jun;16(6):1243-8. PubMed PMID: 10812002.
12: Nakabo Y, Pabst MJ. Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol. 1996 Sep;60(3):328-36. PubMed PMID: 8830789.
13: Wijayanti N, Kietzmann T, Immenschuh S. Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes. J Biol Chem. 2005 Jun 10;280(23):21820-9. Epub 2005 Apr 15. PubMed PMID: 15833736.
14: Beek J, Nauwynck H, Appeltant R, Maes D, Van Soom A. Inhibitors of serine proteases decrease sperm penetration during porcine fertilization in vitro by inhibiting sperm binding to the zona pellucida and acrosome reaction. Theriogenology. 2015 Nov;84(8):1378-86. doi: 10.1016/j.theriogenology.2015.07.022. Epub 2015 Jul 26. PubMed PMID: 26303413.
15: Prévotat L, Filomenko R, Solary E, Jeannin JF, Bettaieb A. Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway. Gastroenterology. 2006 Oct;131(4):1142-52. Epub 2006 Jul 24. PubMed PMID: 17030184.
16: Wang R, Liu S, Wang J, Dong Q, Xu L, Rui Q. Purification, characterization and identification of a senescence related serine protease in dark-induced senescent wheat leaves. Phytochemistry. 2013 Nov;95:118-26. doi: 10.1016/j.phytochem.2013.06.025. Epub 2013 Aug 1. PubMed PMID: 23910959.
17: Basak S, Stewart NA, Chrétien M, Basak A. Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1. FEBS Lett. 2004 Aug 27;573(1-3):186-94. PubMed PMID: 15327996.
18: Trivedi A, Babic S, Chanoine JP. Pitfalls in the determination of human acylated ghrelin plasma concentrations using a double antibody enzyme immunometric assay. Clin Biochem. 2012 Jan;45(1-2):178-80. doi: 10.1016/j.clinbiochem.2011.10.023. Epub 2011 Nov 7. PubMed PMID: 22100897.
19: Karpuzoglu E, Gogal RM Jr, Ansar Ahmed S. Serine protease inhibitor, 4-(2-aminoethyl)-benzene sulfonyl fluoride, impairs IL-12-induced activation of pSTAT4β, NFκB, and select pro-inflammatory mediators from estrogen-treated mice. Immunobiology. 2011 Dec;216(12):1264-73. doi: 10.1016/j.imbio.2011.07.003. Epub 2011 Jul 7. PubMed PMID: 21813204.
20: Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul;17(1):171-9. PubMed PMID: 8755488.

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