6-O-α-Maltosyl-β-cyclodextrin


CAS No. : 104723-60-6

6-O-α-Maltosyl-β-cyclodextrin,104723-60-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000261
Molecular Formula:C54H90O45
Molecular Weight:1459.27
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Cat No:I000261
Cas No:104723-60-6
Product-Name:6-O-α-Maltosyl-β-cyclodextrin

6-O-α-maltosyl-β cyclodextrin (Mal-βCD) is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol and is much less cytotoxic to human erythrocytes and Caco-2 cells; a cyclodextrin derivative.
IC50 value:
Target:
Mal-βCD removes cellular cholesterol forming inclusion complexes, while Mal-βCD-induced lack of cellular cholesterol was replenished by the addition of CLM without cytotoxicity. Cholesterol reduction by Mal-βCD abolishes the mRNA and protein expression of ABCA1 and ABCG1, but not of P-gp.


[1]. Okada Y, et al. Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. Carbohydr Res. 2012 Aug 1;357:68-74.

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