A-317567


CAS No. : 371217-32-2

A-317567,371217-32-2
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000209
Synonyms:A-317567; A 317567; A317567.;6-{2-[2-methyl-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]cyclopropyl}naphthalene-2-carboximidamide
Molecular Formula:C27H31N3
Molecular Weight:397.566
Target:ASIC-3 inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:I000209
Cas No:371217-32-2
Product-Name:A-317567
IUPAC Name:6-[2-(2-methyl-1-propan-2-yl-3,4-dihydro-1H-isoquinolin-7-yl)cyclopropyl]naphthalene-2-carboximidamide
InChI:InChI=1S/C27H31N3/c1-16(2)26-25-14-21(7-4-17(25)10-11-30(26)3)24-15-23(24)20-8-5-19-13-22(27(28)29)9-6-18(19)12-20/h4-9,12-14,16,23-24,26H,10-11,15H2,1-3H3,(H3,28,29)
InChIKey:FEPIUXBUJVISNN-UHFFFAOYSA-N
SMILES:CC(C)C1C2=C(CCN1C)C=CC(=C2)C3CC3C4=CC5=C(C=C4)C=C(C=C5)C(=N)N
A-317567 is an ASIC-3 inhibitor.

1:Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567. Kuduk SD, Di Marco CN, Bodmer-Narkevitch V, Cook SP, Cato MJ, Jovanovska A, Urban MO, Leitl M, Sain N, Liang A, Spencer RH, Kane SA, Hartman GD, Bilodeau MT.ACS Chem Neurosci. 2010 Jan 20;1(1):19-24. doi: 10.1021/cn9000186. Epub 2009 Oct 6. PMID: 22778804 Free PMC Article
2:Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels. Dubé GR, Lehto SG, Breese NM, Baker SJ, Wang X, Matulenko MA, Honoré P, Stewart AO, Moreland RB, Brioni JD.Pain. 2005 Sep;117(1-2):88-96. Erratum in: Pain. 2005 Nov;118(1-2):281. PMID: 16061325
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