MK-2894 sodium salt


CAS No. : 1006036-88-9

MK-2894 sodium salt,1006036-88-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000094
Synonyms:sodium 4-(1-(2,5-dimethyl-4-(4-(trifluoromethyl)benzyl)thiophene-3-carboxamido)cyclopropyl)benzoate
Molecular Formula:C25H21F3NNaO3S
Molecular Weight:495.49
Target:EP4 Receptor
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Cat No:I000094
Cas No:1006036-88-9
Product-Name:MK-2894 sodium salt

MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist.
IC50 value:
Target: EP4
MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.


[1]. Blouin M, Han Y, Burch J, Farand J, Mellon C, Gaudreault M, Wrona M, Lévesque JF, Denis D, Mathieu MC, Stocco R, Vigneault E, Therien A, Clark P, Rowland S, Xu D, O/'Neill G, Ducharme Y, Friesen R. The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist. J Med Chem. 2010 Mar 11;53(5):2227-38. Abstract The discovery of highly potent and selective second generation EP(4) antagonist MK-2894 (34d) is discussed. This compound exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. It also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.

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