Lambrolizumab


CAS No. : 1374853-91-4

Lambrolizumab,1374853-91-4
Product Details
Cat No:A001235
Synonyms:Lambrolizumab;Pembrolizumab
Molecular Formula:NA
Molecular Weight:NA
Target:PD-1
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Cat No:A001235
Cas No:1374853-91-4
Product-Name:Lambrolizumab
Lambrolizumab(CAS 1374853-91-4) is a humanized antibody used in cancer immunotherapy. It blocks a protective mechanism on cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1 (PD-1) receptor. The drug was initially used to treat metastatic melanoma. 
1: Mandel JJ, Olar A, Aldape KD, Tremont-Lukats IW. Lambrolizumab induced central nervous system (CNS) toxicity. J Neurol Sci. 2014 Sep 15;344(1-2):229-31. doi: 10.1016/j.jns.2014.06.023. Epub 2014 Jun 20. PubMed PMID: 24980937; PubMed Central PMCID: PMC4157634.
2: Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS, Dronca R, Gangadhar TC, Patnaik A, Zarour H, Joshua AM, Gergich K, Elassaiss-Schaap J, Algazi A, Mateus C, Boasberg P, Tumeh PC, Chmielowski B, Ebbinghaus SW, Li XN, Kang SP, Ribas A. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. 2013 Jul 11;369(2):134-44. doi: 10.1056/NEJMoa1305133. Epub 2013 Jun 2. PubMed PMID: 23724846; PubMed Central PMCID: PMC4126516.
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