Estradiol


CAS No. : 50-28-2

Estradiol,50-28-2
Product Details
Cat No:A000961
Synonyms:Beta-Estradiol; 17beta-Estradiol; 50-28-2; Oestradiol; Dihydrofolliculin
Molecular Formula:C18H24O2
Molecular Weight:272.4
Target:Estrogen/progestogen Receptor
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Appearance:Solid powder
Purity: > 98%
Cat No:A000961
Cas No:50-28-2
Product-Name:Estradiol
InChI:1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChIKey:VOXZDWNPVJITMN-ZBRFXRBCSA-N
SMILES:CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
Estradiol is an Estrogen. Estradiol is the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.The mechanism of action of estradiol is as an Estrogen Receptor Agonist. Therapeutic Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Typically esterified, estradiol derivatives are formulated for oral or parenteral administration.
1: Grant EJ, Cologne JB, Sharp GB, Eguchi H, Stevens RG, Izumi S, Kim YM, Berrington de González A, Ohishi W, Nakachi K. Serum bioavailable estradiol may alter radiation risk of postmenopausal breast cancer: a nested case-control study. Int J Radiat Biol. 2018 Jan 8:1-27. doi: 10.1080/09553002.2018.1419303. [Epub ahead of print] PubMed PMID: 29307255.
2: Hilderbrand ER, Lasek AW. Estradiol enhances ethanol reward in female mice through activation of ERα and ERβ. Horm Behav. 2018 Jan 3. pii: S0018-506X(17)30463-4. doi: 10.1016/j.yhbeh.2018.01.001. [Epub ahead of print] PubMed PMID: 29305887.
3: Jana B, Meller KA, Czajkowska M, Całka J. Long-term estradiol-17β exposure decreases the cholinergic innervation pattern of the pig ovary. Ann Anat. 2018 Jan 2. pii: S0940-9602(17)30160-7. doi: 10.1016/j.aanat.2017.11.010. [Epub ahead of print] PubMed PMID: 29305268.
4: Wang S, Zhu J, Xu T. 17β-estradiol (E2) promotes growth and stability of new dendritic spines via estrogen receptor β pathway in intact mouse cortex. Brain Res Bull. 2017 Dec 27;137:241-248. doi: 10.1016/j.brainresbull.2017.12.011. [Epub ahead of print] PubMed PMID: 29288734.
5: Pedersen AL, Saldanha CJ. Reciprocal interactions between prostaglandin E2- and estradiol-dependent signaling pathways in the injured zebra finch brain. J Neuroinflammation. 2017 Dec 29;14(1):262. doi: 10.1186/s12974-017-1040-1. PubMed PMID: 29284502; PubMed Central PMCID: PMC5747085.
6: Yan Z, Liu Y, Sun H, Lu G. Influence of multiwall carbon nanotubes on the toxicity of 17β-estradiol in the early life stages of zebrafish. Environ Sci Pollut Res Int. 2017 Dec 27. doi: 10.1007/s11356-017-1063-2. [Epub ahead of print] PubMed PMID: 29282666.
7: Yamaguchi A, Ishibashi H, Kono S, Iida M, Uchida M, Arizono K, Tominaga N. Nanosecond pulsed electric field incorporation technique to predict molecular mechanisms of teratogenicity and developmental toxicity of estradiol-17β on medaka embryos. J Appl Toxicol. 2017 Dec 27. doi: 10.1002/jat.3579. [Epub ahead of print] PubMed PMID: 29280155.
8: Merritt J, Davis M, Jalabert C, Libecap T, Williams D, Soma K, Maney D. Rapid effects of estradiol on aggression depend on genotype in a species with an estrogen receptor polymorphism. Horm Behav. 2017 Dec 22. pii: S0018-506X(17)30350-1. doi: 10.1016/j.yhbeh.2017.11.014. [Epub ahead of print] PubMed PMID: 29277700.
9: Chen XJ, Chen F, Lv PP, Zhang D, Ding GL, Hu XL, Feng C, Sheng JZ, Huang HF. Maternal high estradiol exposure alters CDKN1C and IGF2 expression in human placenta. Placenta. 2018 Jan;61:72-79. doi: 10.1016/j.placenta.2017.11.009. Epub 2017 Nov 14. PubMed PMID: 29277274.
10: Tong JJ, Thompson IM, Zhao X, Lacasse P. Effect of 17β-estradiol on milk production, hormone secretion, and mammary gland gene expression in dairy cows. J Dairy Sci. 2017 Dec 20. pii: S0022-0302(17)31174-8. doi: 10.3168/jds.2017-13353. [Epub ahead of print] PubMed PMID: 29274969.
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