CAS No. : 61413-54-5

Product Details
Cat No:A000755
Synonyms:61413-54-5; ZK 62711; Rolipramum; Rolipramum [Latin]; Adeo
Molecular Formula:C₁₆H₂₁NO₃
Molecular Weight:275.35
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Appearance:Solid powder
Purity: > 98%
Cat No:A000755
Cas No:61413-54-5
MDL No:MFCD00270906
Rolipram is a phosphodiesterase 4 inhibitor potentially for treatment of depression.
1: Ramezani S, Hadjighassem M, Vousooghi N, Parvaresh M, Arbabi F, Amini N, Joghataei MT. The Role of Protein Kinase B Signaling Pathway in Anti-Cancer Effect of Rolipram on Glioblastoma Multiforme: An In Vitro Study. Basic Clin Neurosci. 2017 Jul-Aug;8(4):325-336. doi: 10.18869/nirp.bcn.8.4.325. PubMed PMID: 29158883; PubMed Central PMCID: PMC5683690.
2: Macks C, Gwak SJ, Lynn M, Lee JS. Rolipram-loaded polymeric micelle nanoparticle reduces secondary injury after rat compression spinal cord injury. J Neurotrauma. 2017 Oct 25. doi: 10.1089/neu.2017.5092. [Epub ahead of print] PubMed PMID: 29065765.
3: Pan Y, Xu C, Pan ZK. MKP-1 negative regulates Staphylococcus aureus induced inflammatory responses in Raw264.7 cells: roles of PKA-MKP-1 pathway and enhanced by rolipram. Sci Rep. 2017 Sep 28;7(1):12366. doi: 10.1038/s41598-017-10187-3. PubMed PMID: 28959039; PubMed Central PMCID: PMC5620070.
4: Türker-Kaya S, Komsuoğlu Celikyurt İ, Celikyurt U, Kına A. Inhibition of PDE4 by low doses of rolipram induces changes in lipid and protein components of mice heart. Gen Physiol Biophys. 2017 Aug 24. doi: 10.4149/gpb_2017009. [Epub ahead of print] PubMed PMID: 28836502.
5: Gong MF, Wen RT, Xu Y, Pan JC, Fei N, Zhou YM, Xu JP, Liang JH, Zhang HT. Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents. Psychopharmacology (Berl). 2017 Oct;234(20):3143-3151. doi: 10.1007/s00213-017-4697-3. Epub 2017 Jul 27. PubMed PMID: 28748375.
6: van der Aart J, Salinas C, Dimber R, Pampols-Maso S, Weekes AA, Tonkyn J, Gray FA, Passchier J, Gunn RN, Rabiner EA. Quantification of human brain PDE4 occupancy by GSK356278: A [(11)C](R)-rolipram PET study. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17720868. doi: 10.1177/0271678X17720868. [Epub ahead of print] PubMed PMID: 28737056.
7: Sims CR, Singh SP, Mu S, Gokden N, Zakaria D, Nguyen TC, Mayeux PR. Rolipram Improves Outcome in a Rat Model of Infant Sepsis-Induced Cardiorenal Syndrome. Front Pharmacol. 2017 May 3;8:237. doi: 10.3389/fphar.2017.00237. eCollection 2017. PubMed PMID: 28515693; PubMed Central PMCID: PMC5413568.
8: Kinoshita KI, Muroi Y, Unno T, Ishii T. Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson/'s disease. J Pharmacol Sci. 2017 May;134(1):55-58. doi: 10.1016/j.jphs.2017.04.002. Epub 2017 Apr 17. PubMed PMID: 28456375.
9: Ramezani S, Vousooghi N, Kapourchali FR, Hadjighasem M, Hayat P, Amini N, Joghataei MT. Rolipram potentiates bevacizumab-induced cell death in human glioblastoma stem-like cells. Life Sci. 2017 Mar 15;173:11-19. doi: 10.1016/j.lfs.2017.02.005. Epub 2017 Feb 12. PubMed PMID: 28202289.
10: Guo CH, Bai L, Wu HH, Yang J, Cai GH, Wang X, Wu SX, Ma W. The analgesic effect of rolipram is associated with the inhibition of the activation of the spinal astrocytic JNK/CCL2 pathway in bone cancer pain. Int J Mol Med. 2016 Nov;38(5):1433-1442. doi: 10.3892/ijmm.2016.2763. Epub 2016 Sep 30. PubMed PMID: 28025994; PubMed Central PMCID: PMC5065302.
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