Hydroxychloroquine Sulfate


CAS No. : 747-36-4

Hydroxychloroquine Sulfate,747-36-4
Product Details
Cat No:A000121
Synonyms:NA
Molecular Formula:C18H26ClN3O ? H2SO4
Molecular Weight:434.0
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Appearance:Solid powder
Purity: > 98%
Cat No:A000121
Cas No:747-36-4
Product-Name:Hydroxychloroquine Sulfate
InChI:1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChIKey:JCBIVZZPXRZKTI-UHFFFAOYSA-N
SMILES:CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
Hydroxychloroquine Sulfate is a synthetic derivative of quinolyl with chemotherapeutic and antibiotic properties. Hydroxychloroquine Sulfate acts against erythrocytic malarial parasites by inhibiting plasmodial heme polymerase and through other unknown mechanisms. Hydroxychloroquine also has anti-inflammatory properties and is used in the treatment of rheumatoid arthritis and lupus erythematosus.
1: McHenry AR, Wempe MF, Rice PJ. Stability of Extemporaneously Prepared Hydroxychloroquine Sulfate 25-mg/mL Suspensions in Plastic Bottles and Syringes. Int J Pharm Compd. 2017 May-Jun;21(3):251-254. PubMed PMID: 28557788.
2: Fan HW, Ma ZX, Chen J, Yang XY, Cheng JL, Li YB. Pharmacokinetics and Bioequivalence Study of Hydroxychloroquine Sulfate Tablets in Chinese Healthy Volunteers by LC-MS/MS. Rheumatol Ther. 2015 Dec;2(2):183-195. Epub 2015 Jul 10. PubMed PMID: 27747530; PubMed Central PMCID: PMC4883261.
3: Chen FY, Xue B, Wang H. [Analysis of the clinical efficacy of yiqi fumai injection combined hydroxychloroquine sulfate tablet for treating Sjogren/'s syndrome]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Dec;32(12):1621-3. Chinese. PubMed PMID: 23469599.
4: Liu YM, Chen Q, Zhang MQ, Liu GY, Jia JY, Pu HH, Liu Y, Hu CY, Lu C, Wang W, Cao WE, Song B, Song YX, Zhu JM, Yu C. A parallel design study to assess the bioequivalence of generic and branded hydroxychloroquine sulfate tablets in healthy volunteers. Arzneimittelforschung. 2012 Dec;62(12):644-9. doi: 10.1055/s-0032-1329962. Epub 2012 Nov 8. PubMed PMID: 23138518.
5: Chopra A, Saluja M, Tillu G, Venugopalan A, Narsimulu G, Handa R, Bichile L, Raut A, Sarmukaddam S, Patwardhan B. Comparable efficacy of standardized Ayurveda formulation and hydroxychloroquine sulfate (HCQS) in the treatment of rheumatoid arthritis (RA): a randomized investigator-blind controlled study. Clin Rheumatol. 2012 Feb;31(2):259-69. doi: 10.1007/s10067-011-1809-z. Epub 2011 Jul 20. PubMed PMID: 21773714.
6: Modi S, Rosen T. Micropapular cutaneous sarcoidosis: case series successfully managed with hydroxychloroquine sulfate. Cutis. 2008 Apr;81(4):351-4. PubMed PMID: 18491485.
7: James JA, Kim-Howard XR, Bruner BF, Jonsson MK, McClain MT, Arbuckle MR, Walker C, Dennis GJ, Merrill JT, Harley JB. Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus. Lupus. 2007;16(6):401-9. PubMed PMID: 17664230.
8: Eisen D. Hydroxychloroquine sulfate (Plaquenil) improves oral lichen planus: An open trial. J Am Acad Dermatol. 1993 Apr;28(4):609-12. PubMed PMID: 8463463.
9: Bernstein HN. Ocular safety of hydroxychloroquine sulfate (Plaquenil). South Med J. 1992 Mar;85(3):274-9. Review. PubMed PMID: 1546352.
10: Canadian Hydroxychloroquine Study Group. A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus. N Engl J Med. 1991 Jan 17;324(3):150-4. PubMed PMID: 1984192.

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