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9-Nitro Oleic Acid

9-Nitro Oleic Acid

  • CAT Number: R055019
  • CAS Number: 875685-44-2
  • Molecular Formula: C18H33NO4
  • Molecular Weight: 327.5
  • Purity: ≥95%
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Nitrated unsaturated fatty acids, such as 10-<wbr></wbr> and 12-<wbr></wbr>nitrolinoleate (LNO<sub>2</sub>; Item No. <span class=/itemid/>10037</span>), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-<wbr></wbr>derived signalling molecules. LNO<sub>2</sub> isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 9-<wbr></wbr>Nitrooleate is one of two regioisomers of nitrooleate, the other being 10-<wbr></wbr>nitrooleate (Item No. <span class=/itemid/>10008043</span>) (OA-<wbr></wbr>NO<sub>2</sub>; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions <em>in vivo</em>. Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H<sub>2</sub>O<sub>2</sub> and nitrite, all mediate the nitration of oleic acid. OA-<wbr></wbr>NO<sub>2</sub> is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-<wbr></wbr>NO<sub>2</sub> activates PPARγ approximately 7-<wbr></wbr>fold at a concentration of 1 µM and effectively promotes differentiation 3T3-<wbr></wbr>L1 preadipocytes to adipocytes at 3 µM.

Catalog Number R055019
CAS Number 875685-44-2
Synonyms

(9E)-9-Nitro-9-octadecenoic Acid;

Molecular Formula

C18H33NO4

Purity 95%
Storage -20°C
InChIKey CQOAKBVRRVHWKV-SAPNQHFASA-N

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