For research use only. Not for therapeutic Use.
8-Aminoadenosine（Cat No.:R002667）is a nucleoside analog structurally related to adenosine, characterized by an amino substitution at the 8-position of the adenine ring. It exhibits potent anti-cancer activity by interfering with RNA metabolism, particularly through inhibition of RNA synthesis and depletion of intracellular ATP levels. 8-Aminoadenosine is rapidly phosphorylated within cells and incorporated into RNA, disrupting transcription and inducing apoptosis in cancer cells. It has shown promise in preclinical studies against hematologic malignancies and solid tumors. Its unique mechanism makes it a valuable tool for targeting transcriptionally active cancer cells.
| CAS Number | 3868-33-5 |
| Synonyms | (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Formula | C10H14N6O4 |
| Purity | ≥95% |
| IUPAC Name | (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| InChI | InChI=1S/C10H14N6O4/c11-7-4-8(14-2-13-7)16(10(12)15-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,15)(H2,11,13,14)/t3-,5-,6-,9-/m1/s1 |
| InChIKey | DVGWFQILDUEEGX-UUOKFMHZSA-N |
| SMILES | C1=NC(=C2C(=N1)N(C(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
