7-(β-Hydroxypropyl)theophylline

• CAT Number: R045934
• CAS Number: 603-00-9
• Molecular Formula: C10H14N4O3
• Molecular Weight: 238.2
• Purity: ≥95%
• Synonyms: 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione; 7-(2-Hydroxypropyl)theophylline; (+/-)-Proxyphyllin; 1,3-Dimethyl-7-(2-hydroxypropyl)?xanthine; Brontyl; Hydroxypropyltheophylline; Monophylline; NSC 163343; Oxypropyltheophylline; Pro
• Target: Adenosine Receptor
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• InChIKey: KYHQZNGJUGFTGR-UHFFFAOYSA-N

Proxyphylline is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.

Reference

1:Antianaphylactic and antiasthmatic properties of new piperazinyl 7-(beta-hydroxypropyl)-theophylline derivatives in guinea pigs. Czarnecki R, Librowski T, Pawłowski M.Pol J Pharmacol. 2001 Mar-Apr;53(2):131-6. PMID: 11787952 Free Article2:[Hypolipemic and antiatherogenic effects of 2/’,4/’ dichlorobenzoate of 7-gamma(beta-hydroxypropyl)-theophylline (HME2)]. Wójcicki J, Samochowiec L, Bartłomowicz B, Kadłubowska D, Marona H.Acta Pol Pharm. 1988;45(4):362-8. Polish. No abstract available. PMID: 3245473 3:Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Selvig K, Bjerve KS.Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2. PMID: 6291318 4:[The polymorphism of 7-(beta-hydroxypropyl)- and 7-(beta, gamma-dihydroxypropyl) theophylline]. Eckert T, Müller J.Arch Pharm (Weinheim). 1977 Jan;310(1):70-5. German. No abstract available. PMID: 843200 5:Gas chromatographic determination of 7-(beta-hydroxypropyl) theophylline in biological fluids. Ervik M.Acta Pharm Suec. 1970 Dec;7(6):697-700. No abstract available. PMID: 5511719 6:[Colorimetric assay of 7-(beta-hydroxypropyl)-theophylline and other purines]. Marini Scotti M.Boll Chim Farm. 1965 Jun;104(6):356-61. Italian. No abstract available. PMID: 5841210