6-Amino-5-azacytidine - CAS 105331-00-8
6-Amino-5-azacytidine (Cat No.:R045299), also known as Vadimezan or ASA404, is an experimental anticancer compound. It belongs to the class of hypoxia-activated prodrugs (HAPs) designed to target and kill hypoxic cancer cells. Under low oxygen conditions, Vadimezan undergoes bioreductive activation, generating toxic metabolites that selectively destroy cancer cells. Clinical trials have been conducted in non-small cell lung cancer and soft tissue sarcoma.
Catalog Number: R045299
CAS Number: 105331-00-8
PubChem Substance ID:355135648
Molecular Formula: C8H13N5O5
Molecular Weight:259.22
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
Synonyms | 4,6-Diamino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one |
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Property
Molecular Formula: | C8H13N5O5 |
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Molecular Weight | 259.22 |
Purity | ≥95% |
Storage | Store at -20°C |
Computed Descriptor
IUPAC Name | 4,6-diamino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one |
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InChI | InChI=1S/C8H13N5O5/c9-6-11-7(10)13(8(17)12-6)5-4(16)3(15)2(1-14)18-5/h2-5,14-16H,1H2,(H4,9,10,11,12,17)/t2-,3-,4-,5-/m1/s1 |
InChIKey | HHBIDXKTBPRKSK-TXICZTDVSA-N |
SMILES | C(C1C(C(C(O1)N2C(=NC(=NC2=O)N)N)O)O)O |