6-Amino-5-azacytidine - CAS 105331-00-8

6-Amino-5-azacytidine (Cat No.:R045299), also known as Vadimezan or ASA404, is an experimental anticancer compound. It belongs to the class of hypoxia-activated prodrugs (HAPs) designed to target and kill hypoxic cancer cells. Under low oxygen conditions, Vadimezan undergoes bioreductive activation, generating toxic metabolites that selectively destroy cancer cells. Clinical trials have been conducted in non-small cell lung cancer and soft tissue sarcoma.

Catalog Number: R045299

CAS Number: 105331-00-8

PubChem Substance ID:355135648

Molecular Formula: C8H13N5O5

Molecular Weight:259.22

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms4,6-Diamino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Property

Molecular Formula: C8H13N5O5
Molecular Weight259.22
Purity≥95%
StorageStore at -20°C

Computed Descriptor

IUPAC Name4,6-diamino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
InChIInChI=1S/C8H13N5O5/c9-6-11-7(10)13(8(17)12-6)5-4(16)3(15)2(1-14)18-5/h2-5,14-16H,1H2,(H4,9,10,11,12,17)/t2-,3-,4-,5-/m1/s1
InChIKeyHHBIDXKTBPRKSK-TXICZTDVSA-N
SMILESC(C1C(C(C(O1)N2C(=NC(=NC2=O)N)N)O)O)O