5-R-Rivaroxaban

• CAT Number: I005204
• CAS Number: 865479-71-6
• Molecular Formula: C19H18ClN3O5S
• Molecular Weight: 435.88
• Purity: ≥95%
• Target: Thrombin
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

5-R-Rivaroxaban is (R) enantiomer of Rivaroxaban. Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders.IC50 value:Target: Factor XaRivaroxaban (Xarelto; BAY 59-7939) inhibits clot-associated,free FXa activity,and prothrombinase activity, in addition, it reduces thrombin generation. Rivaroxaban (Xarelto; BAY 59-7939) is useful for antithrombotic agent.

Reference

[1]. Beyer-Westendorf J, Lützner J, Donath L, Radke OC, Kuhlisch E, Hartmann A, Weiss N, Werth S.
Efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopaedic surgery – findings from the ortho-tep registry.
J Thromb Haemost. 2012 Aug 6. doi: 10.1111/j.1538-7836.2012.04877.x.

[2]. Helbing T, Bode C, Moser M.
Rivaroxaban in the prevention and treatment of thromboembolic disorders.Hamostaseologie. 2012 Aug 1;32(3):195-202.

[3]. Clavé A, Fazilleau F, Dumser D, Lacroix J.
Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement with rivaroxaban thromboprophylaxis: A case-control study in 70 patients.
Orthop Traumatol Surg Res. 2012 Apr 27.

[4]. Mani H, Rohde G, Stratmann G, Hesse C, Herth N, Schwers S, Perzborn E, Lindhoff-Last E.
Accurate determination of rivaroxaban levels requires different calibrator sets but not addition of antithrombin.
Thromb Haemost. 2012 Jul 3;108(1):191-8.

[5]. Duggan ST.
Rivaroxaban: a review of its use for the prophylaxis of venous thromboembolism after total hip or knee replacement surgery.
Am J Cardiovasc Drugs. 2012 Feb 1;12(1):57-72. doi: 10.2165/11208470-000000000-00000.