5'-O-TBDMS-dT

• CAT Number: I044606
• CAS Number: 40733-28-6
• Molecular Formula: C16H28N2O5Si
• Molecular Weight: 356.49
• Purity: ≥95%
• Synonyms: 1-[(2R,4S,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
• InChI: InChI=1S/C16H28N2O5Si/c1-10-8-18(15(21)17-14(10)20)13-7-11(19)12(23-13)9-22-24(5,6)16(2,3)4/h8,11-13,19H,7,9H2,1-6H3,(H,17,20,21)/t11-,12+,13+/m0/s1
• InChIKey: IJWIJLIIOKZJMS-YNEHKIRRSA-N
• SMILES: CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[Si](C)(C)C(C)(C)C)O

5′-O-TBDMS-dT（Cat No.:I044606）is a protected deoxyribonucleoside phosphoramidite based on deoxythymidine (dT), featuring a 5′-O-tert-butyldimethylsilyl (TBDMS) group that shields the 5′-hydroxyl functionality. The TBDMS group provides strong, acid- and base-resistant protection, ideal for multistep or orthogonal oligonucleotide synthesis. It enables selective deprotection using fluoride-based reagents, allowing precise control in complex synthetic schemes. 5′-O-TBDMS-dT is commonly used in the synthesis of modified or chimeric DNA strands for applications in therapeutic development, molecular diagnostics, and nucleic acid structural studies, where high chemical stability and selective reactivity are essential.