For research use only. Not for therapeutic Use.
5′-O-DMT-2′-O-TBDMS-rI（Cat No.:I044600）is a protected ribonucleoside used as a building block in the chemical synthesis of RNA oligonucleotides. It features a 5′-O-dimethoxytrityl (DMT) group for 5′-hydroxyl protection and a 2′-O-tert-butyldimethylsilyl (TBDMS) group to protect the 2′-hydroxyl, ensuring selective reactivity during solid-phase synthesis. The base component, rI (ribonucleoside inosine), is important in RNA editing and wobble base pairing. This compound allows for the efficient and high-fidelity synthesis of modified RNA strands, which are essential in structural biology, therapeutic RNA design, and advanced nucleic acid research.
| CAS Number | 127212-34-4 |
| Synonyms | 9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-1H-purin-6-one |
| Molecular Formula | C37H44N4O7Si |
| Purity | ≥95% |
| IUPAC Name | 9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-1H-purin-6-one |
| InChI | InChI=1S/C37H44N4O7Si/c1-36(2,3)49(6,7)48-32-31(42)29(47-35(32)41-23-40-30-33(41)38-22-39-34(30)43)21-46-37(24-11-9-8-10-12-24,25-13-17-27(44-4)18-14-25)26-15-19-28(45-5)20-16-26/h8-20,22-23,29,31-32,35,42H,21H2,1-7H3,(H,38,39,43)/t29-,31-,32-,35-/m1/s1 |
| InChIKey | OPTOBSYBLQDPQN-QSYCCZFCSA-N |
| SMILES | CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=CNC3=O)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
