5-Iodo-indirubin-3'-monoxime

• CAT Number: I019230
• CAS Number: 331467-03-9
• Molecular Formula: C₁₆H₁₀IN₃O₂
• Molecular Weight: 403.17
• Purity: ≥95%

5-Iodo-indirubin-3′-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively[1].

Reference

[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.