5-Hydroxy L-Tryptophan

• CAT Number: R056784
• CAS Number: 4350-09-8
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.228
• Purity: ≥95%
• Storage: Room temperature
• IUPAC Name: (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
• InChI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
• InChIKey: LDCYZAJDBXYCGN-VIFPVBQESA-N
• SMILES: C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N

Oxitriptan (Cat.No:R056784) is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan. It is used as an antiepileptic and antidepressant.

Reference

1:Enhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration. Hara R, Kino K.AMB Express. 2013 Dec 9;3(1):70. doi: 10.1186/2191-0855-3-70. PMID: 24321061 Free PMC Article2:Feeding 5-hydroxy-l-tryptophan during the transition from pregnancy to lactation increases calcium mobilization from bone in rats. Laporta J, Peters TL, Weaver SR, Merriman KE, Hernandez LL.Domest Anim Endocrinol. 2013 May;44(4):176-84. doi: 10.1016/j.domaniend.2013.01.005. Epub 2013 Feb 15. PMID: 23433710 3:5-hydroxy-L-tryptophan Suppressed Food Intake in Rats Despite an Increase in the Arcuate NPY Expression. Moon YW, Choi SH, Yoo SB, Lee JH, Jahng JW.Exp Neurobiol. 2010 Dec;19(3):132-9. doi: 10.5607/en.2010.19.3.132. Epub 2010 Dec 31. PMID: 22110352 Free PMC Article4:Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat. Baumann MH, Williams Z, Zolkowska D, Rothman RB.Drug Alcohol Depend. 2011 Apr 1;114(2-3):147-52. doi: 10.1016/j.drugalcdep.2010.09.015. Epub 2010 Nov 10. PMID: 21071157 Free PMC Article5:5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination. Larsen M, Holm R, Jensen KG, Sveigaard C, Brodin B, Nielsen CU.Eur J Pharm Sci. 2010 Jan 31;39(1-3):68-75. doi: 10.1016/j.ejps.2009.10.013. Epub 2009 Nov 10. PMID: 19900542 6:Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats. Ma Z, Zhang G, Jenney C, Krishnamoorthy S, Tao R.Eur J Pharmacol. 2008 Jul 7;588(2-3):198-206. doi: 10.1016/j.ejphar.2008.04.004. Epub 2008 Apr 8. PMID: 18499101 Free PMC Article7:A new application of pre-normalized principal component analysis for improvement of image quality and clinical diagnosis in human brain PET studies–clinical brain studies using [11C]-GR205171, [11C]-L-deuterium-deprenyl, [11C]-5-Hydroxy-L-Tryptophan, [11C]-L-DOPA and Pittsburgh Compound-B. Razifar P, Axelsson J, Schneider H, Långström B, Bengtsson E, Bergström M.Neuroimage. 2006 Nov 1;33(2):588-98. Epub 2006 Aug 24. PMID: 16934493 8:Alterations in alcohol consumption, withdrawal seizures, and monoamine transmission in rats treated with phentermine and 5-hydroxy-L-tryptophan. Halladay AK, Wagner GC, Sekowski A, Rothman RB, Baumann MH, Fisher H.Synapse. 2006 Apr;59(5):277-89. PMID: 16416445 9:Safety of 5-hydroxy-L-tryptophan. Das YT, Bagchi M, Bagchi D, Preuss HG.Toxicol Lett. 2004 Apr 15;150(1):111-22. Review. PMID: 15068828 10:5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats. Amer A, Breu J, McDermott J, Wurtman RJ, Maher TJ.Pharmacol Biochem Behav. 2004 Jan;77(1):137-43. PMID: 14724051