For research use only. Not for therapeutic Use.
5′-DMT-3′-TBDMS-ibu-rG（Cat No.:I045042）is a chemically modified ribonucleoside used in RNA synthesis and oligonucleotide research. It features a 5′-dimethoxytrityl (DMT) protecting group for controlled 5′-end coupling, a 3′-tert-butyldimethylsilyl (TBDMS) group protecting the 3′-hydroxyl, and an isobutyryl (ibu) protecting group on the guanine base (rG). These protective groups enable selective and sequential incorporation of the nucleoside during solid-phase RNA synthesis. 5′-DMT-3′-TBDMS-ibu-rG is essential in producing high-fidelity RNA oligonucleotides for use in molecular biology, structural studies, and therapeutic research targeting RNA structure, function, and gene expression.
| CAS Number | 81256-89-5 |
| Synonyms | N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide |
| Molecular Formula | C41H51N5O8Si |
| Purity | ≥95% |
| IUPAC Name | N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide |
| InChI | InChI=1S/C41H51N5O8Si/c1-25(2)36(48)44-39-43-35-32(37(49)45-39)42-24-46(35)38-33(47)34(54-55(8,9)40(3,4)5)31(53-38)23-52-41(26-13-11-10-12-14-26,27-15-19-29(50-6)20-16-27)28-17-21-30(51-7)22-18-28/h10-22,24-25,31,33-34,38,47H,23H2,1-9H3,(H2,43,44,45,48,49)/t31-,33-,34-,38-/m1/s1 |
| InChIKey | XAIQBZNFPUNWMQ-CJEGOSRCSA-N |
| SMILES | CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O[Si](C)(C)C(C)(C)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
