5-Bromo-2-fluorobenzonitrile

• CAT Number: M042786
• CAS Number: 179897-89-3
• Molecular Formula: C7H3BrFN
• Molecular Weight: 200.01
• Purity: ≥95%
• Storage: Desiccate at -20C
• IUPAC Name: 5-bromo-2-fluorobenzonitrile
• InChI: InChI=1S/C7H3BrFN/c8-6-1-2-7(9)5(3-6)4-10/h1-3H
• InChIKey: GYCNHFWRPJXTSB-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1Br)C#N)F

5-Bromo-2-fluorobenzonitrile (CAS 179897-89-3) may be used for the preparation of the following compounds:
(E)-5-(2-cyclopropylvinyl)-<wbr style="color: rgb(102, 94, 88); font-family: Arial, Helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;" />2-fluorobenzonitrile and methyl-3-amino-5-bromoben<wbr style="color: rgb(102, 94, 88); font-family: Arial, Helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;" />zo[b]thiophene-2-carboxylate,
(S)-[2-[5-(3-cyano-4-fluoro<wbr style="color: rgb(102, 94, 88); font-family: Arial, Helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;" />-phenyl)-pyridin-3-yloxy]<wbr style="color: rgb(102, 94, 88); font-family: Arial, Helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;" />-1-(1H-indol-3-ylmethyl)-ethyl]<wbr style="color: rgb(102, 94, 88); font-family: Arial, Helvetica, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;" />-carbamic acid tert-butyl ester,
4-fluoro-3-cyano-3′-tributyltinbenzhydrol and 4-fluoro-3-cyano-3′-iodobenzhydrol.

Reference

1.Bagley, Mark C., et al. "Microwave-assisted synthesis of 3-aminobenzo [b] thiophene scaffolds for the preparation of kinase inhibitors." Organic & Biomolecular Chemistry 13.24 (2015): 6814-6824.
2.Woods, Keith W., et al. "Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors." Bioorganic & medicinal chemistry 14.20 (2006): 6832-6846.
3.Li, Zizhong, et al. "Synthesis of structurally identical fluorine-18 and iodine isotope labeling compounds for comparative imaging." Bioconjugate chemistry 14.2 (2003): 287-294.